Preheat the oven to 450 degrees F (230 degrees C).

Place bacon in a large skillet and cook over medium-high heat, turning occasionally, until evenly browned, about 10 minutes. Drain bacon slices on paper towels. Let cool enough to handle; crumble.

Combine flour, baking powder, baking soda, and salt in a bowl and cut in shortening until it resembles coarse crumbs. Add buttermilk and stir just enough to form a ball. Fold in crumbled bacon and Cheddar cheese.

Drop heaping tablespoonfuls on an ungreased baking sheet.

Bake in the preheated oven until golden brown, 10 to 12 minutes. Serve immediately.