Place 1/4 cup jelly beans in a small bowl and pour vodka over the top. Cover the bowl with plastic wrap and refrigerate until chilled, at least 30 minutes.
Fill a shaker with ice. Shake bowl with chilled jelly beans and vodka, pour mixture through a strainer into shaker, and discard jelly beans. Pour orange liqueur and creme de cacao into shaker and stir. Strain vodka mixture into 2 chilled martini glasses. Drop 1 white jelly bean and 1 red jelly bean into the bottom of each glass and place 1 lemon slice on each rim.