Heat a large pot over medium-high heat. Cook and stir beef, onion, and garlic in the hot pot until ground beef is browned and crumbly, 5 to 7 minutes; drain and discard grease. Mix chili powder, cumin, onion powder, cayenne pepper, salt, and black pepper into ground beef.
Stir tomatoes, hot chili beans, chili beans, tomato sauce, green chile peppers, jalapeno peppers, lime juice, and hot sauce into ground beef mixture; bring to a boil. Reduce heat and simmer until flavors blend, at least 30 minutes.